Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase–deficient mice and primary cells despite increased chromosomal instability

Poly(ADP-ribose) polymerase (PARP)-1, a detector of single-strand breaks, plays a key role in the cellular response to DNA damage. PARP-1–deficient mice are hypersensitive to genotoxic agents and display genomic instability due to a DNA repair defect in the base excision repair pathway. A previous r...

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Autori principali: Samper, Enrique, Goytisolo, Fermín A., Murcia, Josiane Ménissier-de, González-Suárez, Eva, Cigudosa, Juan C., de Murcia, Gilbert, Blasco, María A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2001
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196874/
https://ncbi.nlm.nih.gov/pubmed/11448989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200103049
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