Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase–deficient mice and primary cells despite increased chromosomal instability

Poly(ADP-ribose) polymerase (PARP)-1, a detector of single-strand breaks, plays a key role in the cellular response to DNA damage. PARP-1–deficient mice are hypersensitive to genotoxic agents and display genomic instability due to a DNA repair defect in the base excision repair pathway. A previous r...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Samper, Enrique, Goytisolo, Fermín A., Murcia, Josiane Ménissier-de, González-Suárez, Eva, Cigudosa, Juan C., de Murcia, Gilbert, Blasco, María A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196874/
https://ncbi.nlm.nih.gov/pubmed/11448989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200103049
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados