Collaborative role of E2F transcriptional activity and G(1) cyclindependent kinase activity in the induction of S phase

A considerable body of evidence points to a role for both cyclin E/cyclin-dependent kinase (cdk)2 activity and E2F transcription activity in the induction of S phase. We show that overexpression of cyclin E/cdk2 in quiescent cells induces S phase, that this coincides with an induction of E2F activit...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Leone, Gustavo, DeGregori, James, Jakoi, Laszlo, Cook, Jeanette G., Nevins, Joseph R.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1999
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21965/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359762/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.12.6626
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