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Collaborative role of E2F transcriptional activity and G(1) cyclindependent kinase activity in the induction of S phase

A considerable body of evidence points to a role for both cyclin E/cyclin-dependent kinase (cdk)2 activity and E2F transcription activity in the induction of S phase. We show that overexpression of cyclin E/cdk2 in quiescent cells induces S phase, that this coincides with an induction of E2F activit...

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Detalhes bibliográficos
Main Authors: Leone, Gustavo, DeGregori, James, Jakoi, Laszlo, Cook, Jeanette G., Nevins, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21965/
https://ncbi.nlm.nih.gov/pubmed/10359762
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