The Active Site of ICP47, a Herpes Simplex Virus–encoded Inhibitor of the Major Histocompatibility Complex (MHC)-encoded Peptide Transporter Associated with Antigen Processing (TAP), Maps to the NH(2)-terminal 35 Residues

The herpes simplex virus (HSV) immediate early protein ICP47 inhibits the transporter associated with antigen processing (TAP)-dependent peptide translocation. As a consequence, empty major histocompatibility complex (MHC) class I molecules are retained in the endoplasmic reticulum and recognition o...

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Main Authors: Galocha, Begoña, Hill, Ann, Barnett, Barbara C., Dolan, Aidan, Raimondi, Alejandra, Cook, Richard F., Brunner, Joseph, McGeoch, Duncan J., Ploegh, Hidde L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1997
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196299/
https://ncbi.nlm.nih.gov/pubmed/9151894
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