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NF-κB RelA-deficient Lymphocytes: Normal Development of  T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

To investigate the function of NF-κB RelA (p65), we generated mice deficient in this NF-κB family member by homologous recombination. Mice lacking RelA showed liver degeneration and died around embryonic day 14.5. To elucidate the role of RelA in lymphocyte development and function, we transplanted...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Doi, Takahiro S., Takahashi, Toshitada, Taguchi, Osamu, Azuma, Takachika, Obata, Yuichi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 1997
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196168/
https://ncbi.nlm.nih.gov/pubmed/9120401
Etiketak: Etiketa erantsi
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