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NF-κB RelA-deficient Lymphocytes: Normal Development of  T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

To investigate the function of NF-κB RelA (p65), we generated mice deficient in this NF-κB family member by homologous recombination. Mice lacking RelA showed liver degeneration and died around embryonic day 14.5. To elucidate the role of RelA in lymphocyte development and function, we transplanted...

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Main Authors: Doi, Takahiro S., Takahashi, Toshitada, Taguchi, Osamu, Azuma, Takachika, Obata, Yuichi
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 1997
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196168/
https://ncbi.nlm.nih.gov/pubmed/9120401
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