Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality
Mice lacking the RelA (p65) subunit of NF-κB die between days 14 and 15 of embryogenesis because of massive liver destruction. Fibroblasts and macrophages isolated from relA−/− embryos were found to be highly sensitive to tumor necrosis factor (TNF) cytotoxicity, raising the possibility that endogen...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15883/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10077625/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.6.2994 |
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