Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality

Mice lacking the RelA (p65) subunit of NF-κB die between days 14 and 15 of embryogenesis because of massive liver destruction. Fibroblasts and macrophages isolated from relA−/− embryos were found to be highly sensitive to tumor necrosis factor (TNF) cytotoxicity, raising the possibility that endogen...

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Detalles Bibliográficos
Main Authors: Doi, Takahiro S., Marino, Michael W., Takahashi, Toshitada, Yoshida, Toshimichi, Sakakura, Teruyo, Old, Lloyd J., Obata, Yuichi
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC15883/
https://ncbi.nlm.nih.gov/pubmed/10077625
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