Nanobody-mediated control of long RSH Rel and RelA catalysis by restriction of their conformational landscape

Abstract Long RSH enzymes, Rel and RelA, are master regulators of bacterial (p)ppGpp alarmones levels. Bifunctional Rel transitions between a compact hydrolysis-competent (HDON) state, a relaxed catalytically inactive (HDOFF/SYNTHOFF) state, and an elongated synthesis-competent (SYNTHON) state, wher...

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Detaylı Bibliyografya
Asıl Yazarlar:	Katleen Van Nerom, Andres Ainelo, Kyo Coppieters ‘t Wallant, Ariel Talavera-Perez, Dannele Echemendia-Blanco, Sarah Peeters, Brahim El Khalfaoui Oulali, Hedvig Tamman, Tatsuaki Kurata, Mohammad Roghanian, Chloé Martens, Els Pardon, Jan Steyaert, Vasili Hauryliuk, Abel Garcia-Pino
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Nature Portfolio 2026-05-01
Seri Bilgileri:	Nature Communications
Online Erişim:	https://doi.org/10.1038/s41467-026-73059-3
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!

Nanobody-mediated control of long RSH Rel and RelA catalysis by restriction of their conformational landscape

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