Anti–4-1bb Monoclonal Antibodies Abrogate T Cell–Dependent Humoral Immune Responses in Vivo through the Induction of Helper T Cell Anergy

The 4-1BB receptor (CDw137), a member of the tumor necrosis factor receptor superfamily, has been shown to costimulate the activation of T cells. Here we show that anti–mouse 4-1BB monoclonal antibodies (mAbs) inhibit thymus-dependent antibody production by B cells. Injection of anti–4-1BB mAbs into...

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Hlavní autoři: Mittler, Robert S., Bailey, Tina S., Klussman, Kerry, Trailsmith, Mark D., Hoffmann, Michael K.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 1999
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195697/
https://ncbi.nlm.nih.gov/pubmed/10562327
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