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Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction
PTEN is thought to play a critical role in T cell activation by negatively regulating the PI3K signaling pathway important for cellular activation, growth, and proliferation. To directly eliminate PTEN in post-thymic T cells for studies of functional effects, we utilized CAR Tg x PTEN(flox/flox) mic...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3759681/ https://ncbi.nlm.nih.gov/pubmed/23851688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202018 |
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