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NMR structure of an α-L-LNA:RNA hybrid: structural implications for RNase H recognition
α-L-LNA (α-L-ribo configured locked nucleic acid) is a nucleotide analogue that raises the thermostability of nucleic acid duplexes by up to ∼4°C per inclusion. We have determined the NMR structure of a nonamer α-L-LNA:RNA hybrid with three α-L-LNA modifications. The geometry of this hybrid is inter...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC219478/ https://ncbi.nlm.nih.gov/pubmed/14530434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg800 |
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