NMR structure of an α-L-LNA:RNA hybrid: structural implications for RNase H recognition

α-L-LNA (α-L-ribo configured locked nucleic acid) is a nucleotide analogue that raises the thermostability of nucleic acid duplexes by up to ∼4°C per inclusion. We have determined the NMR structure of a nonamer α-L-LNA:RNA hybrid with three α-L-LNA modifications. The geometry of this hybrid is inter...

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Bibliographic Details
Main Authors: Nielsen, Jakob T., Stein, Paul C., Petersen, Michael
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC219478/
https://ncbi.nlm.nih.gov/pubmed/14530434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg800
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