A versatile approach to multiple gene RNA interference using microRNA-based short hairpin RNAs

BACKGROUND: Effective and stable knockdown of multiple gene targets by RNA interference is often necessary to overcome isoform redundancy, but it remains a technical challenge when working with intractable cell systems. RESULTS: We have developed a flexible platform using RNA polymerase II promoter-...

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Detalhes bibliográficos
Main Authors: Zhu, Xiaocui, Santat, Leah A, Chang, Mi Sook, Liu, Jamie, Zavzavadjian, Joelle R, Wall, Estelle A, Kivork, Christine, Simon, Melvin I, Fraser, Iain DC
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194719/
https://ncbi.nlm.nih.gov/pubmed/17971228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-8-98
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