A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

Although Toll-like receptors (TLRs) are critical mediators of the immune response to pathogens, the influence of polymorphisms in this gene family on human susceptibility to infection is poorly understood. We demonstrated recently that TLR5 recognizes flagellin, a potent inflammatory stimulus presen...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Hawn, Thomas R., Verbon, Annelies, Lettinga, Kamilla D., Zhao, Lue Ping, Li, Shuying Sue, Laws, Richard J., Skerrett, Shawn J., Beutler, Bruce, Schroeder, Lea, Nachman, Alex, Ozinsky, Adrian, Smith, Kelly D., Aderem, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194120/
https://ncbi.nlm.nih.gov/pubmed/14623910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031220
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados