A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

Although Toll-like receptors (TLRs) are critical mediators of the immune response to pathogens, the influence of polymorphisms in this gene family on human susceptibility to infection is poorly understood. We demonstrated recently that TLR5 recognizes flagellin, a potent inflammatory stimulus presen...

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Autors principals: Hawn, Thomas R., Verbon, Annelies, Lettinga, Kamilla D., Zhao, Lue Ping, Li, Shuying Sue, Laws, Richard J., Skerrett, Shawn J., Beutler, Bruce, Schroeder, Lea, Nachman, Alex, Ozinsky, Adrian, Smith, Kelly D., Aderem, Alan
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2003
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194120/
https://ncbi.nlm.nih.gov/pubmed/14623910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031220
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