Chronic Lymphocytic Leukemia B Cells Can Undergo Somatic Hypermutation and Intraclonal Immunoglobulin V(H)DJ(H) Gene Diversification

Chronic lymphocytic leukemia (CLL) arises from the clonal expansion of a CD5(+) B lymphocyte that is thought not to undergo intraclonal diversification. Using V(H)DJ(H) cDNA single strand conformation polymorphism analyses, we detected intraclonal mobility variants in 11 of 18 CLL cases. cDNA sequen...

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Main Authors: Gurrieri, Carmela, McGuire, Peter, Zan, Hong, Yan, Xiao-Jie, Cerutti, Andrea, Albesiano, Emilia, Allen, Steven L., Vinciguerra, Vincent, Rai, Kanti R., Ferrarini, Manlio, Casali, Paolo, Chiorazzi, Nicholas
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2002
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194006/
https://ncbi.nlm.nih.gov/pubmed/12208878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011693
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