CD8β Endows CD8 with Efficient Coreceptor Function by Coupling T Cell Receptor/CD3 to Raft-associated CD8/p56(lck) Complexes

The extraordinary sensitivity of CD8(+) T cells to recognize antigen impinges to a large extent on the coreceptor CD8. While several studies have shown that the CD8β chain endows CD8 with efficient coreceptor function, the molecular basis for this is enigmatic. Here we report that cell-associated CD...

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Main Authors: Arcaro, Alexandre, Grégoire, Claude, Bakker, Talitha R., Baldi, Lucia, Jordan, Martin, Goffin, Laurence, Boucheron, Nicole, Wurm, Florian, van der Merwe, P. Anton, Malissen, Bernard, Luescher, Immanuel F.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2001
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193676/
https://ncbi.nlm.nih.gov/pubmed/11714755
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