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Knock-in Mutation of the Distal Four Tyrosines of Linker for Activation of T Cells Blocks Murine T Cell Development

The integral membrane adapter protein linker for activation of T cells (LAT) performs a critical function in T cell antigen receptor (TCR) signal transduction by coupling the TCR to downstream signaling pathways. After TCR engagement, LAT is tyrosine phosphorylated by ZAP-70 creating docking sites f...

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Autors principals: Sommers, Connie L., Menon, Rashmi K., Grinberg, Alexander, Zhang, Weiguo, Samelson, Lawrence E., Love, Paul E.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193454/
https://ncbi.nlm.nih.gov/pubmed/11457888
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