Interleukin (Il)-4 Is a Major Regulatory Cytokine Governing Bioactive IL-12 Production by Mouse and Human Dendritic Cells

Interleukin (IL)-12 may be secreted as a bioactive T helper type 1 (Th1) cell–inducing heterodimer, as a monomer, or as an antagonistic homodimer. We analyzed the IL-12 produced by mouse splenic dendritic cells (DCs), human thymic DCs, and cultured human monocyte-derived DCs. IL-12 production requir...

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Autores principales: Hochrein, Hubertus, O'Keeffe, Meredith, Luft, Thomas, Vandenabeele, Stéphane, Grumont, Raelene J., Maraskovsky, Eugene, Shortman, Ken
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2000
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193283/
https://ncbi.nlm.nih.gov/pubmed/10993913
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