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p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement

Rearrangement of the immunoglobulin (Ig) and T cell receptor (TCR) gene loci allows for the generation of B and T lymphocytes with antigen- specific receptors. Complete rearrangement and expression of the TCR- beta chain enables immature thymocytes to differentiate from the CD4- CD8- to the CD4+CD8+...

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Detalhes bibliográficos
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1996
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2192529/
https://ncbi.nlm.nih.gov/pubmed/8666950
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