Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency

Ionizing radiation induces clustered DNA damage, which presents a challenge to the cellular repair machinery. The repair efficiency of a single-strand break (SSB) is ∼4× less than that for repair of an abasic (AP) site when in a bistranded cluster containing 8-oxoG. To explore whether this differenc...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Mourgues, Sophie, Lomax, Martine E., O’Neill, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2007
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2190709/
https://ncbi.nlm.nih.gov/pubmed/17982170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm947
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker