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Contributions of DNA interstrand cross-links to aging of cells and organisms
Impaired DNA damage repair, especially deficient transcription-coupled nucleotide excision repair, leads to segmental progeroid syndromes in human patients as well as in rodent models. Furthermore, DNA double-strand break signalling has been pinpointed as a key inducer of cellular senescence. Severa...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2190700/ https://ncbi.nlm.nih.gov/pubmed/18083760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1065 |
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