Region-dependent attenuation of μ opioid receptor-mediated G-protein activation in mouse CNS as a function of morphine tolerance

BACKGROUND AND PURPOSE: Chronic morphine administration produces tolerance in vivo and attenuation of μ opioid receptor (MOR)-mediated G-protein activation measured in vitro, but the relationship between these adaptations is not clear. The present study examined MOR-mediated G-protein activation in...

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Detalhes bibliográficos
Main Authors: Sim-Selley, L J, Scoggins, K L, Cassidy, M P, Smith, L A, Dewey, W L, Smith, F L, Selley, D E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2189837/
https://ncbi.nlm.nih.gov/pubmed/17572699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707328
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