Pharmacophore modelling of stereoselective binding to the human organic cation transporter (hOCT1)

BACKGROUND AND PURPOSE: The human organic cation transporter-1 (hOCT1) is a polyspecific transporter that plays a role in drug distribution, metabolism and excretion. Previous studies have demonstrated that hOCT1 binding can be stereoselective, but the mechanism for stereochemical recognition has no...

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Main Authors: Moaddel, R, Ravichandran, S, Bighi, F, Yamaguchi, R, Wainer, I W
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2007
主題:
Research Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2189821/
https://ncbi.nlm.nih.gov/pubmed/17592512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707341
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