The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses

In patients with celiac disease, inflammatory T cell responses to HLA-DQ2-bound gluten peptides are thought to cause disease. Two types of HLA-DQ2 molecules exist, termed HLA-DQ2.5 and HLA-DQ2.2. Whereas HLA-DQ2.5 predisposes to celiac disease, HLA-DQ2.2 does not. We now provide evidence that the di...

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Autori principali: Vader, Willemijn, Stepniak, Dariusz, Kooy, Yvonne, Mearin, Luisa, Thompson, Allan, van Rood, Jon J., Spaenij, Liesbeth, Koning, Frits
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC218768/
https://ncbi.nlm.nih.gov/pubmed/14530392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2135229100
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