Zinc-finger protein-targeted gene regulation: Genomewide single-gene specificity

Zinc-finger protein transcription factors (ZFP TFs) can be designed to control the expression of any desired target gene, and thus provide potential therapeutic tools for the study and treatment of disease. Here we report that a ZFP TF can repress target gene expression with single-gene specificity...

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Main Authors: Tan, Siyuan, Guschin, Dmitry, Davalos, Albert, Lee, Ya-Li, Snowden, Andrew W., Jouvenot, Yann, Zhang, H. Steven, Howes, Katherine, McNamara, Andrew R., Lai, Albert, Ullman, Chris, Reynolds, Lindsey, Moore, Michael, Isalan, Mark, Berg, Lutz-Peter, Campos, Bradley, Qi, Hong, Spratt, S. Kaye, Case, Casey C., Pabo, Carl O., Campisi, Judith, Gregory, Philip D.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2003
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC218702/
https://ncbi.nlm.nih.gov/pubmed/14514889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2035056100
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