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Ataxin-2 mediated cell death is dependent on domains downstream of the polyQ repeat
Spinocerebellar ataxia 2 (SCA2) belongs to the group of neurodegenerative diseases caused by expansion of a polyglutamine (polyQ) domain. Overexpression of mutant ataxin-2 causes cell death and Golgi dispersion in cell culture as well as morphologic and functional changes in mouse models. To further...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2186298/ https://ncbi.nlm.nih.gov/pubmed/17949716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2007.07.023 |
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