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Ataxin-2 mediated cell death is dependent on domains downstream of the polyQ repeat

Spinocerebellar ataxia 2 (SCA2) belongs to the group of neurodegenerative diseases caused by expansion of a polyglutamine (polyQ) domain. Overexpression of mutant ataxin-2 causes cell death and Golgi dispersion in cell culture as well as morphologic and functional changes in mouse models. To further...

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Bibliografske podrobnosti
Main Authors: Ng, Hiushan, Pulst, Stefan-M, Huynh, Duong P.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2186298/
https://ncbi.nlm.nih.gov/pubmed/17949716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2007.07.023
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