PCP and MK-801 Induced Behaviors Reduced by NAAG Peptidase Inhibition via Metabotropic Glutamate Receptors

BACKGROUND: NMDA receptor open channel blockers phencyclidine (PCP) and dizocilpine (MK-801) elicit schizophrenia-like symptoms in humans and in animal models. Group II metabotropic glutamate receptor agonists reverse the behavioral effects of PCP and MK-801 in animal models. N-Acetylaspartylglutama...

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Autori principali: Olszewski, Rafal T., Wegorzewska, Marta M., Monteiro, Ana C., Krolikowski, Kristyn A., Zhou, Jia, Kozikowski, Alan P., Long, Katrice, Mastropaolo, John, Deutsch, Stephen I., Neale, Joseph H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2185547/
https://ncbi.nlm.nih.gov/pubmed/17597589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2007.04.016
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