NAAG peptidase inhibitors block cognitive deficit induced by MK-801 and motor activation induced by d-amphetamine in animal models of schizophrenia

The most widely validated animal models of the positive, negative and cognitive symptoms of schizophrenia involve administration of d-amphetamine or the open channel NMDA receptor blockers, dizocilpine (MK-801), phencyclidine (PCP) and ketamine. The drug ZJ43 potently inhibits glutamate carboxypepti...

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Detalhes bibliográficos
Main Authors: Olszewski, R T, Janczura, K J, Ball, S R, Madore, J C, Lavin, K M, Lee, J C-M, Lee, M J, Der, E K, Hark, T J, Farago, P R, Profaci, C P, Bzdega, T, Neale, J H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410622/
https://ncbi.nlm.nih.gov/pubmed/22850437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2012.68
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