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Group II mGluR agonist LY354740 and NAAG peptidase inhibitor effects on prepulse inhibition in PCP and D-amphetamine models of schizophrenia

RATIONALE: Group II metabotropic glutamate receptor (mGluR) agonists represent a novel approach to the treatment of schizophrenia. Inasmuch as the peptide neurotransmitter N-acetylaspartylglutamate (NAAG) activates these receptors, NAAG peptidase inhibitors conceptually represent a parallel path tow...

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Detalhes bibliográficos
Main Authors: Profaci, Caterina P., Krolikowski, Kristyn A., Olszewski, Rafal T., Neale, Joseph H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108005/
https://ncbi.nlm.nih.gov/pubmed/21327758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-011-2200-0
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