Plaque-induced neurite abnormalities: Implications for disruption of neural networks in Alzheimer’s disease

The brains of Alzheimer’s disease patients contain extracellular Aβ amyloid deposits (senile plaques). Although genetic evidence causally links Aβ deposition to the disease, the mechanism by which Aβ disrupts cortical function is unknown. Using triple immunofluorescent confocal microscopy and three-...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Knowles, Roger B., Wyart, Claire, Buldyrev, Sergey V., Cruz, Luis, Urbanc, Brigita, Hasselmo, Michael E., Stanley, H. Eugene, Hyman, Bradley T.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1999
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21854/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10220456/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.9.5274
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