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Plaque-induced neurite abnormalities: Implications for disruption of neural networks in Alzheimer’s disease

The brains of Alzheimer’s disease patients contain extracellular Aβ amyloid deposits (senile plaques). Although genetic evidence causally links Aβ deposition to the disease, the mechanism by which Aβ disrupts cortical function is unknown. Using triple immunofluorescent confocal microscopy and three-...

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Detalhes bibliográficos
Main Authors: Knowles, Roger B., Wyart, Claire, Buldyrev, Sergey V., Cruz, Luis, Urbanc, Brigita, Hasselmo, Michael E., Stanley, H. Eugene, Hyman, Bradley T.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21854/
https://ncbi.nlm.nih.gov/pubmed/10220456
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