The intracellular domain of interferon-α receptor 2c (IFN-αR2c) chain is responsible for Stat activation

Type I IFNs activate the Jak–Stat signal transduction pathway. The IFN-α receptor 1 (IFN-αR1) subunit and two splice variants of the IFN-αR2 subunit, IFN-αR2c and IFN-αR2b, are involved in ligand binding. All these receptors have been implicated in cytokine signaling and, specifically, in Stat recru...

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Detalles Bibliográficos
Main Authors: Kotenko, Serguei V., Izotova, Lara S., Mirochnitchenko, Olga V., Lee, Carolyn, Pestka, Sidney
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC21807/
https://ncbi.nlm.nih.gov/pubmed/10220409
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