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LIGAND-INDEPENDENT INTERACTION OF THE TYPE I INTERFERON RECEPTOR COMPLEX IS NECESSARY TO OBSERVE ITS BIOLOGICAL ACTIVITY
Ectopic coexpression of the two chains of the Type I and Type III interferon (IFN) receptor complexes (IFN-αR1 and IFN-αR2c, or IFN-λR1 and IL-10R2) yielded sensitivity to IFN-alpha or IFN-lambda in only some cells. We found that IFN-αR1 and IFN-αR2c exhibit FRET only when expressed at equivalent an...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3770802/ https://ncbi.nlm.nih.gov/pubmed/23830819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2013.06.309 |
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