LIGAND-INDEPENDENT INTERACTION OF THE TYPE I INTERFERON RECEPTOR COMPLEX IS NECESSARY TO OBSERVE ITS BIOLOGICAL ACTIVITY

Ectopic coexpression of the two chains of the Type I and Type III interferon (IFN) receptor complexes (IFN-αR1 and IFN-αR2c, or IFN-λR1 and IL-10R2) yielded sensitivity to IFN-alpha or IFN-lambda in only some cells. We found that IFN-αR1 and IFN-αR2c exhibit FRET only when expressed at equivalent an...

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Main Authors: Krause, Christopher D., Digioia, Gina, Izotova, Lara S., Xie, Junxia, Kim, Youngsun, Schwartz, Barbara J., Mirochnitchenko, Olga V., Pestka, Sidney
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770802/
https://ncbi.nlm.nih.gov/pubmed/23830819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2013.06.309
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