A mutant of Mycobacterium tuberculosis lacking the 19-kilodalton lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties

A mutant of Mycobacterium tuberculosis (Δ19) lacking the 19kDa lipoprotein grows well in culture in vitro but was shown here to be essentially incapable of any significant replication in mice, even in mice lacking the gamma interferon gene. Despite this, mice inoculated with Δ19 were equally protect...

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Main Authors: Henao-Tamayo, Marcela, Junqueira-Kipnis, Ana Paula, Ordway, Diane, Gonzales-Juarrero, Mercedes, Stewart, Graham R., Young, Douglas B., Wilkinson, Robert J., Basaraba, Randall J., Orme, Ian M.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2180418/
https://ncbi.nlm.nih.gov/pubmed/17804126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2007.07.042
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