A Mutant of Mycobacterium tuberculosis H37Rv That Lacks Expression of Antigen 85A Is Attenuated in Mice but Retains Vaccinogenic Potential

The fbpA and fbpB genes encoding the 85A and 85B proteins of Mycobacterium tuberculosis H37Rv, respectively, were disrupted, the mutants were examined for their ability to survive, and the strain lacking 85A (ΔfbpA) was tested for its ability to immunize mice. The ΔfbpA mutant was attenuated in mice...

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Bibliographic Details
Main Authors: Copenhaver, Robert H., Sepulveda, Eliud, Armitige, Lisa Y., Actor, Jeffrey K., Wanger, Audrey, Norris, Steven J., Hunter, Robert L., Jagannath, Chinnaswamy
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC529100/
https://ncbi.nlm.nih.gov/pubmed/15557632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.12.7084-7095.2004
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