Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

Rationale: In experimental models, lung fibrosis is dependent on transforming growth factor (TGF)-β signaling. TGF-β is secreted in a latent complex with its propeptide, and TGF-β activators release TGF-β from this complex. Because the integrin αvβ6 is a major TGF-β activator in the lung, inhibition...

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Main Authors: Puthawala, Khalid, Hadjiangelis, Nicos, Jacoby, Steven C., Bayongan, Emmanuel, Zhao, Zhicheng, Yang, Zhiwei, Devitt, Mary Louise, Horan, Gerald S., Weinreb, Paul H., Lukashev, Matvey E., Violette, Shelia M., Grant, Kristen S., Colarossi, Cristina, Formenti, Silvia C., Munger, John S.
格式: Artigo
語言:Inglês
出版: American Thoracic Society 2008
主題:
E. Interstitial Lung Disease
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2176115/
https://ncbi.nlm.nih.gov/pubmed/17916808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200706-806OC
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