Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

Rationale: In experimental models, lung fibrosis is dependent on transforming growth factor (TGF)-β signaling. TGF-β is secreted in a latent complex with its propeptide, and TGF-β activators release TGF-β from this complex. Because the integrin αvβ6 is a major TGF-β activator in the lung, inhibition...

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Autori principali: Puthawala, Khalid, Hadjiangelis, Nicos, Jacoby, Steven C., Bayongan, Emmanuel, Zhao, Zhicheng, Yang, Zhiwei, Devitt, Mary Louise, Horan, Gerald S., Weinreb, Paul H., Lukashev, Matvey E., Violette, Shelia M., Grant, Kristen S., Colarossi, Cristina, Formenti, Silvia C., Munger, John S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2008
Soggetti:
E. Interstitial Lung Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2176115/
https://ncbi.nlm.nih.gov/pubmed/17916808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200706-806OC
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