Preservation of Mitochondrial Structure and Function after Bid- or Bax-Mediated Cytochrome c Release

Proapoptotic members of the Bcl-2 protein family, including Bid and Bax, can activate apoptosis by directly interacting with mitochondria to cause cytochrome c translocation from the intermembrane space into the cytoplasm, thereby triggering Apaf-1–mediated caspase activation. Under some circumstanc...

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Main Authors: von Ahsen, Oliver, Renken, Christian, Perkins, Guy, Kluck, Ruth M., Bossy-Wetzel, Ella, Newmeyer, Donald D.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2000
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175243/
https://ncbi.nlm.nih.gov/pubmed/10973993
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