P(0) Glycoprotein Overexpression Causes Congenital Hypomyelination of Peripheral Nerves

We show that normal peripheral nerve myelination depends on strict dosage of the most abundantly expressed myelin gene, myelin protein zero (Mpz). Transgenic mice containing extra copies of Mpz manifested a dose-dependent, dysmyelinating neuropathy, ranging from transient perinatal hypomyelination t...

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Bibliografiske detaljer
Main Authors: Wrabetz, Lawrence, Feltri, Maria Laura, Quattrini, Angelo, Imperiale, Daniele, Previtali, Stefano, D'Antonio, Maurizio, Martini, Rudolf, Yin, Xinghua, Trapp, Bruce D., Zhou, Lei, Chiu, Shing-Yan, Messing, Albee
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2000
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174542/
https://ncbi.nlm.nih.gov/pubmed/10704451
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