pRB plays an essential role in cell cycle arrest induced by DNA damage

To maintain genome stability, cells with damaged DNA must arrest to allow repair of mutations before replication. Although several key components required to elicit this arrest have been discovered, much of the pathway remains elusive. Here we report that pRB acts as a central mediator of the prolif...

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Main Authors: Harrington, Elizabeth A., Bruce, Jacqueline L., Harlow, Ed, Dyson, Nicholas
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 1998
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC21745/
https://ncbi.nlm.nih.gov/pubmed/9751770
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