Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor

Death receptors can trigger cell demise dependent or independent of caspases. In WEHI-S fibrosarcoma cells, tumor necrosis factor (TNF) induced an increase in cytosolic cathepsin B activity followed by death with apoptotic features. Surprisingly, this process was enhanced by low, but effectively inh...

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Hauptverfasser: Foghsgaard, Lasse, Wissing, Dorte, Mauch, Daniel, Lademann, Ulrik, Bastholm, Lone, Boes, Marianne, Elling, Folmer, Leist, Marcel, Jäättelä, Marja
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2001
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174340/
https://ncbi.nlm.nih.gov/pubmed/11381085
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