The Tyrosine Kinase Activity of c-Src Regulates Actin Dynamics and Organization of Podosomes in Osteoclasts

Podosomes are dynamic actin-rich structures composed of a dense F-actin core surrounded by a cloud of more diffuse F-actin. Src performs one or more unique functions in osteoclasts (OCLs), and podosome belts and bone resorption are impaired in the absence of Src. Using Src(−/−) OCLs, we investigated...

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Hlavní autoři: Destaing, Olivier, Sanjay, Archana, Itzstein, Cecile, Horne, William C., Toomre, Derek, De Camilli, Pietro, Baron, Roland
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174183/
https://ncbi.nlm.nih.gov/pubmed/17978100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-03-0227
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