Characterization of unique functionalities in c-Src domains required for osteoclast podosome belt formation

Deletion of c-Src, a ubiquitously expressed tyrosine kinase, results in osteoclast dysfunction and osteopetrosis, in which bones harden into “stone.” In contrast, deletion of the genes encoding other members of the Src family kinase (SFK) fails to produce an osteopetrotic phenotype. This suggests th...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Matsubara, Takuma, Addison, William N., Kokabu, Shoichiro, Neff, Lynn, Horne, William, Gori, Francesca, Baron, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8196221/
https://ncbi.nlm.nih.gov/pubmed/34019873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100790
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