Characterization of unique functionalities in c-Src domains required for osteoclast podosome belt formation

Deletion of c-Src, a ubiquitously expressed tyrosine kinase, results in osteoclast dysfunction and osteopetrosis, in which bones harden into “stone.” In contrast, deletion of the genes encoding other members of the Src family kinase (SFK) fails to produce an osteopetrotic phenotype. This suggests th...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Matsubara, Takuma, Addison, William N., Kokabu, Shoichiro, Neff, Lynn, Horne, William, Gori, Francesca, Baron, Roland
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8196221/
https://ncbi.nlm.nih.gov/pubmed/34019873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100790
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