Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(−/−) mice

The protein tyrosine kinase Pyk2 is highly expressed in osteoclasts, where it is primarily localized in podosomes. Deletion of Pyk2 in mice leads to mild osteopetrosis due to impairment in osteoclast function. Pyk2-null osteoclasts were unable to transform podosome clusters into a podosome belt at t...

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Detalhes bibliográficos
Main Authors: Gil-Henn, Hava, Destaing, Olivier, Sims, Natalie A., Aoki, Kazuhiro, Alles, Neil, Neff, Lynn, Sanjay, Archana, Bruzzaniti, Angela, De Camilli, Pietro, Baron, Roland, Schlessinger, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064627/
https://ncbi.nlm.nih.gov/pubmed/17846174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200701148
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