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Huntingtin toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

The cause of Huntington's disease is expansion of polyglutamine (polyQ) domain in huntingtin, which makes this protein both neurotoxic and aggregation prone. Here we developed the first yeast model, which establishes a direct link between aggregation of expanded polyQ domain and its cytotoxicit...

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Bibliografski detalji
Glavni autori: Meriin, Anatoli B., Zhang, Xiaoqian, He, Xiangwei, Newnam, Gary P., Chernoff, Yury O., Sherman, Michael Y.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174031/
https://ncbi.nlm.nih.gov/pubmed/12058016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200112104
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