Polyglutamine Toxicity Is Controlled by Prion Composition and Gene Dosage in Yeast

Polyglutamine expansion causes diseases in humans and other mammals. One example is Huntington's disease. Fragments of human huntingtin protein having an expanded polyglutamine stretch form aggregates and cause cytotoxicity in yeast cells bearing endogenous QN-rich proteins in the aggregated (p...

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Main Authors: Gong, He, Romanova, Nina V., Allen, Kim D., Chandramowlishwaran, Pavithra, Gokhale, Kavita, Newnam, Gary P., Mieczkowski, Piotr, Sherman, Michael Y., Chernoff, Yury O.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334884/
https://ncbi.nlm.nih.gov/pubmed/22536159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002634
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